Elevated butyric acid and histamine in feces and serum as an indicator of onset of necrotic enteritis in broiler chickens
This study highlights metabolic differences in birds with NE and underscores butyric acid and histamine as potential early biomarkers for NE diagnosis. The upregulation of these metabolites across serum, jejunal and fecal samples reflects their local and systemic impacts on the disease. These biomarkers play key roles in several NE hallmark features, including gut barrier disruption, dysbiosis of microbes and tissue injury through immune system activation, and systemic inflammation. Future studies need to validate our findings across field conditions and different predisposing factors.
Authors
- David S. Wishart (ORCID: https://orcid.org/0000-0002-3207-2434)
- Betty Chow-Lockerbie
- Suresh K. Tikoo (ORCID: https://orcid.org/0000-0003-4697-0179)
- Shelly Popowich
- Susantha Gomis (ORCID: https://orcid.org/0000-0003-2431-7339)
- Babajan Banaganapalli
- Lisanework E. Ayalew (ORCID: https://orcid.org/0000-0002-4157-9552)
- Rupasri Mandal
- Hemlata Gautam
- Shaik Noor Ahmad
Institutions
- University of Alberta (CA)
- King Abdulaziz University (SA)
- University of Prince Edward Island (CA)
- University of Saskatchewan (CA)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1581309
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministry of Agriculture - Saskatchewan
- Chicken Farmers of Saskatchewan
- Natural Sciences and Engineering Research Council of Canada