Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing
CN PJI presents a unique microbial spectrum and distinct clinical therapeutic characteristics. mNGS offers a more comprehensive understanding of infecting microorganisms, particularly those often missed by conventional culture techniques. With advancements in sample collection, optimized culture methods, molecular diagnostic tools, and early targeted therapies, CN PJI may achieve clinical outcomes comparable to CP PJI.
Authors
- Mingzhong Liu
- Baijian Wu (ORCID: https://orcid.org/0000-0002-5738-6595)
- Canhong Zhang
- Jiayu Li
- Xinyu Fang (ORCID: https://orcid.org/0000-0001-6337-8009)
- Wenbo Li (ORCID: https://orcid.org/0000-0002-0199-1534)
- Juncheng Li (ORCID: https://orcid.org/0000-0003-2915-5076)
- Wenming Zhang (ORCID: https://orcid.org/0000-0002-8101-4089)
- Lan Lin
- Zida Huang
- Jianhua Lv
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1564488
- Citations
- 6
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- Natural Science Foundation of Fujian Province