Magnetization transfer MRI of third trimester fetal brain: a pilot of gestational myelin imaging
The developed YB MT pulse sequence is sensitive to fetal physiological MT signal is tolerable to participants, and does not demonstrate sensitivity to ST confounds in phantom imaging. While the breath hold was reported to be tolerable, motion artefacts and spiral trajectory blurring affected subjects' imaging. Ongoing work, including online reconstruction, expedited trajectories, and improvements in the signal-to-noise ratio should address these challenges. This proof of principle is a step towards the clinical translation of gestational metabolic imaging, such as MT imaging of fetal myelin, for the early detection of gestational complications.
Authors
- Siddharth Sadanand (ORCID: https://orcid.org/0000-0001-7316-5699)
- Tim Van Mieghem (ORCID: https://orcid.org/0000-0002-3034-6905)
- Dafna Sussman (ORCID: https://orcid.org/0000-0001-9977-3131)
- Elka Miller (ORCID: https://orcid.org/0000-0003-1075-5952)
- Greg J. Stanisz (ORCID: https://orcid.org/0000-0002-9488-7612)
- Shiri Shinar (ORCID: https://orcid.org/0000-0001-6352-4846)
- Robert Stobbe (ORCID: https://orcid.org/0000-0002-6223-5222)
- Pradeep Krishnan (ORCID: https://orcid.org/0000-0003-0598-091X)
Institutions
- Mount Sinai Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University of Alberta (CA)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fped.2025.1443387
- Citations
- 1
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Hospital for Sick Children
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada