Reduced immune response to SARS-CoV-2 infection in the elderly after 6 months
Omicron BA.5 infection induced lower neutralizing antibodies against XBB.1 and EG.5 variant. The decrease of memory B cells, CD69<sup>+</sup> and CD38<sup>+</sup>T cells, as well as the increase of PD-1<sup>+</sup>, CTLA-4<sup>+</sup> of CD4<sup>+</sup>/CD8<sup>+</sup>T cells and double negative B cells, indicate that sustained immune responses against BA.5 infection may wane more rapidly in elderly populations.
Authors
- Haijun Du (ORCID: https://orcid.org/0000-0001-5425-5488)
- Guanhua Xue (ORCID: https://orcid.org/0000-0002-7091-265X)
- Juan Song (ORCID: https://orcid.org/0000-0001-7350-9578)
- Jun Han (ORCID: https://orcid.org/0000-0002-5192-3433)
- Kexin Zong
- Yan Li (ORCID: https://orcid.org/0000-0001-7612-3953)
- Mi Liu (ORCID: https://orcid.org/0000-0002-6508-0115)
- Qin Luo
- Chen Gao (ORCID: https://orcid.org/0000-0002-9768-3877)
- Junming He (ORCID: https://orcid.org/0000-0003-3261-4202)
- Zhongjun Dong (ORCID: https://orcid.org/0000-0002-2155-231X)
- Zengqiang Kou (ORCID: https://orcid.org/0009-0006-2879-5855)
- Yuxin Qu
- Dong Xia
- Qinqin Song
- Zhiqiang Xia
- Wenyan Tian (ORCID: https://orcid.org/0000-0003-3427-6016)
- Ti Liu (ORCID: https://orcid.org/0000-0002-7773-9677)
- Guo-yong Mei (ORCID: https://orcid.org/0009-0009-3489-4712)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- National Institute for Viral Disease Control and Prevention (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Shandong Center for Disease Control and Prevention (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1596065
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79