Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis
Our findings suggest that the hcBAC-exos-C22:6-TLR4-IL-1β signaling pathway plays a crucial role in the context of RA, indicating the potential clinical applications of hcBAC-exos in the treatment of inflammatory conditions such as rheumatoid arthritis.
Authors
- Ziyu Cheng
- Gang Sun (ORCID: https://orcid.org/0000-0002-1862-2268)
- Wanzhu Jin (ORCID: https://orcid.org/0000-0002-5860-2958)
- Rongcai Ye
- Rui Jiang (ORCID: https://orcid.org/0000-0001-8046-5323)
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-1649-3378)
- Qiaoli Zhang (ORCID: https://orcid.org/0000-0003-4596-0665)
- Zhi Zhang (ORCID: https://orcid.org/0000-0002-6022-0510)
- Yuanyuan Huang (ORCID: https://orcid.org/0009-0006-1631-8322)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-2508-4912)
- Meng Dong (ORCID: https://orcid.org/0000-0002-8523-8602)
- Yujian Zhang (ORCID: https://orcid.org/0000-0002-7293-051X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Henan University of Engineering (CN)
- University of Chinese Academy of Sciences (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1543288
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Major Research Plan
- National Key Research and Development Program of China