PWRN1 low expression facilitates cancer progression and is an unfavorable prognosis factor in breast cancer
PWRN1 may be a prognostic marker for TNBC. Overexpression of PWRN1 leads to low expression of miR-21-5p, which affects cell proliferation, migration, and invasive behaviors, thereby preventing poor prognosis in TNBC patients.
Authors
- Dezhen Yang (ORCID: https://orcid.org/0000-0002-7183-6492)
- Yuanwei Liu (ORCID: https://orcid.org/0000-0002-6389-8941)
- Ming Dong (ORCID: https://orcid.org/0000-0002-0226-6975)
- Yong Jia (ORCID: https://orcid.org/0000-0002-4201-6591)
- Xiaodong Yang (ORCID: https://orcid.org/0000-0002-8168-5026)
- Xin Tang (ORCID: https://orcid.org/0000-0002-4451-8405)
- Hubao Yuan
Institutions
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1007/s12672-025-02538-8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00