Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes
Our study shows that MIF stimulation of chondrocytes can activate the ERK/PLA2G4A signaling pathway and increase AA production. ProCs located in the proliferative layer of cartilage are likely the main cells executing this mechanism. Therefore, targeting and inhibiting MIF signaling in chondrocytes, especially in ProCs, could be a novel strategy for the prevention and treatment of OA.
Authors
- Linlin Tao (ORCID: https://orcid.org/0000-0001-7612-9909)
- Haihua Luo (ORCID: https://orcid.org/0000-0003-4607-9917)
- Aolin Jiang
- Yong Jiang (ORCID: https://orcid.org/0000-0002-2824-677X)
- Zhaoqian Zhong (ORCID: https://orcid.org/0000-0001-5930-4488)
- Kan Xing Wu (ORCID: https://orcid.org/0000-0002-1389-2226)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
Institutions
- University of Science and Technology of China (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmed.2025.1552029
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Southern Medical University