Clostridium Butyricum 337279 shapes the gut microbiota to attenuate metabolic disorder in diet-induced obese mice
<i>C.B</i> intervention significantly ameliorated gut microbiota imbalance in obese mice and alleviated obesity-related metabolic disorders by upregulating the expression of tight junction proteins (ZO-1 and occludin), attenuating endotoxemia and systemic inflammation and reducing microbial-derived BCAA production.
Authors
- Haipeng Sun (ORCID: https://orcid.org/0000-0003-2128-3209)
- Junjun Cao (ORCID: https://orcid.org/0000-0003-4523-6896)
- Wenyan Niu (ORCID: https://orcid.org/0000-0001-7481-1576)
- Zhiyu Li (ORCID: https://orcid.org/0009-0003-3886-981X)
- Xuejiao Zhang (ORCID: https://orcid.org/0000-0001-9349-5687)
Institutions
- Tianjin Infectious Diseases Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1580847
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Tianjin Science and Technology Committee