Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALL
These findings provide proof-of-concept that NKG2D-based tandem CARs offer a promising approach to overcome antigen escape and enhance anti-tumor efficacy in B-cell malignancies.
Authors
- Jennifer Bolsée
- Céline Jacques-Hespel
- Benjamin Violle
- Eytan Breman (ORCID: https://orcid.org/0000-0002-3562-7781)
- Caroline Lonez (ORCID: https://orcid.org/0000-0002-9230-3855)
- Thùy Linh Nguyễn (ORCID: https://orcid.org/0000-0001-7943-5012)
Institutions
- Celyad (Belgium) (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1557405
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.23