Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice
Our study highlights the prowess of chemical checkpoint inhibitors, exemplified by CCT007093, in alleviating immune exhaustion in HBV-infected mice, particularly by enhancing adaptive immunity.
Authors
- Chia‐Lang Hsu (ORCID: https://orcid.org/0000-0002-7447-8045)
- Shiang‐Jong Tzeng (ORCID: https://orcid.org/0000-0003-1633-020X)
- Huiying Wang (ORCID: https://orcid.org/0009-0001-3229-2365)
- Wan-Ting Chang
- Yan-Fong Lu (ORCID: https://orcid.org/0000-0002-9458-5470)
- Yu-Syuan You
- InKyeom Kim
Institutions
- National Taiwan University (TW)
- Kyungpook National University (KR)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1548814
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Council
- National Health Research Institutes
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council