Mycobacterium abscessus persistence in the face of Pseudomonas aeruginosa antagonism

The study showed <i>Mab</i> is capable of coexisting with <i>Pa</i> despite <i>Pa</i>'s antagonistic effects, eliciting an adaptive molecular response in <i>Mab</i>. This study provides the first transcriptome-level insight into genetic interactions between the two CF pathogens offering potential strategies for disrupting their communities in a CF lung to improve patient clinical performance. Moreover, identification of a novel antimicrobial natural product with potent cidal activity against <i>Mab</i> could lead to new drug targets and therapies for Mab infections.