Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle
BAT-derived exosomes in T2DM reduce ITPR3 expression in endothelial cells, lowering intracellular Ca<sup>2+</sup> and NO production, thereby contributing to vascular endothelium-dependent relaxation dysfunction. Targeting this pathway may offer therapeutic insights for T2DM-associated vascular complications.
Authors
- Xiaojie Ruan (ORCID: https://orcid.org/0009-0006-5605-0076)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-1785-2037)
Institutions
- Ningxia Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fcvm.2025.1546325
- Citations
- 3
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Chinese University of Hong Kong