Secretor and non-secretor human milk oligosaccharides differentially modulate immune response in the presence of cow’s milk allergen β-lactoglobulin in an in vitro sensitization model
Se+ and Se- pHMOs with BLG differentially affected moDC activation. Se+ pHMO-pre-exposed moDCs induced a type 2- and regulatory-associated T cell phenotype. These data suggest that depending on the secretor status, HMOs differentially modulate immune responsiveness <i>in vitro</i>.
Authors
- Johan Garssen (ORCID: https://orcid.org/0000-0002-8678-9182)
- Anneke H. Hellinga (ORCID: https://orcid.org/0000-0001-8516-7253)
- Belinda van’t Land (ORCID: https://orcid.org/0000-0001-8601-5032)
- Aletta D. Kraneveld (ORCID: https://orcid.org/0000-0001-9819-383X)
- Kennedy Spann
- Marit Zuurveld (ORCID: https://orcid.org/0000-0002-5948-0358)
- Marko Mank (ORCID: https://orcid.org/0000-0001-7695-3906)
- Lars Bode (ORCID: https://orcid.org/0000-0002-9914-9571)
- Linette E. M. Willemsen (ORCID: https://orcid.org/0000-0001-9882-5331)
Institutions
- Center for Global Development (US)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Vrije Universiteit Amsterdam (NL)
- Global University (LB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1575656
- Citations
- 3
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- Universitair Medisch Centrum Utrecht