Carbapenem-resistant Gram-negative bacteria exhibiting clinically undetected cefiderocol heteroresistance leads to treatment failure in a murine model of infection
These findings highlight the clinical significance of CFD-HR, even in susceptible isolates, and underscore the need for improved diagnostic methods to detect HR and monitor cross-resistance, offering critical insights for regions transitioning to CFD implementation.
Authors
- Linhai Li (ORCID: https://orcid.org/0000-0003-3923-0404)
- Yingfeng Zhang (ORCID: https://orcid.org/0000-0001-9547-381X)
- Lingqing Xu (ORCID: https://orcid.org/0000-0003-4630-7721)
- Wenchang Yuan
- Peng Zhou (ORCID: https://orcid.org/0000-0002-6665-3800)
- Hongwei Liu (ORCID: https://orcid.org/0000-0003-2501-7813)
- Qiwei Li (ORCID: https://orcid.org/0009-0003-1469-6504)
- Yaqin Liu (ORCID: https://orcid.org/0000-0002-6982-1849)
- Weiguo Yin
- Lu Yang (ORCID: https://orcid.org/0000-0003-3373-6391)
- Peng Ma (ORCID: https://orcid.org/0009-0009-4720-5322)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Kingmed Diagnostics (CN)
- Qingzhou City People's Hospital (CN)
- University of South China (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1496514
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Natural Science Foundation of Guangdong Province
- Guangzhou University of Chinese Medicine
- Guangzhou University