Parsing Clinical and Neurobiological Sources of Heterogeneity in Depression
The study identified distinct neuroimaging profiles related to particular clinical depression features that may explain inconsistencies in the literature and subclusters within the acute impairment group with cognitive differences that were only differentiable by neuroimaging. Our results provide evidence that multiple neuroimaging profiles may give rise to the same clinical presentation, emphasizing the presence of complex interactions between clinical and neuroimaging sources of heterogeneity.
Authors
- Aristeidis Sotiras (ORCID: https://orcid.org/0000-0003-0795-8820)
- Deanna M. Barch (ORCID: https://orcid.org/0000-0003-1693-8506)
- Ty Easley (ORCID: https://orcid.org/0000-0002-8215-2598)
- Janine Bijsterbosch (ORCID: https://orcid.org/0000-0002-1385-9178)
- André F. Marquand (ORCID: https://orcid.org/0000-0001-5903-203X)
- Daphne Lew (ORCID: https://orcid.org/0000-0001-5433-2367)
- Yvette I. Sheline (ORCID: https://orcid.org/0000-0002-6929-9659)
- Kayla Hannon (ORCID: https://orcid.org/0000-0002-6340-6791)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-6428-2033)
Institutions
- Radboud University Nijmegen (NL)
- Washington University in St. Louis (US)
- Radboud University Medical Center (NL)
- Institute for Medical Informatics and Biostatistics (CH)
- University of Pennsylvania (US)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.biopsych.2025.04.025
- Citations
- 3
- Primary Topic
- Personality Disorders and Psychopathology
- Type
- article
- Field-Weighted Citation Impact
- 6.92
Funders
- BrightFocus Foundation
- National Institutes of Health
- Washington University School of Medicine in St. Louis