Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID
In this study of 16 people with Long COVID, vaccination is associated with increased SARS-CoV-2 spike protein-specific IgG and T cell expansion in most participants. Specific immune features are associated with symptom change after vaccination and most participants experience improved health or no change following vaccination.
Authors
- Jeph Herrin (ORCID: https://orcid.org/0000-0002-3671-3622)
- Hannah Wei (ORCID: https://orcid.org/0000-0002-0307-7498)
- Leying Guan (ORCID: https://orcid.org/0000-0003-0609-1073)
- Julio Silva (ORCID: https://orcid.org/0000-0001-8212-7440)
- Bornali Bhattacharjee (ORCID: https://orcid.org/0000-0002-0801-1543)
- Connor B. Grady (ORCID: https://orcid.org/0000-0001-8407-846X)
- Jillian R. Jaycox (ORCID: https://orcid.org/0000-0003-0919-5679)
- Akiko Iwasaki (ORCID: https://orcid.org/0000-0002-7824-9856)
- Jeff Gehlhausen (ORCID: https://orcid.org/0000-0002-7659-1105)
- Wade L. Schulz (ORCID: https://orcid.org/0000-0002-2048-4028)
- Charles S. Dela Cruz (ORCID: https://orcid.org/0000-0002-5258-1797)
- Valter Silva Monteiro (ORCID: https://orcid.org/0000-0003-1785-6713)
- Daniel O. Griffin (ORCID: https://orcid.org/0000-0001-5853-6906)
- Lik Wee Lee (ORCID: https://orcid.org/0000-0001-6412-6153)
- Tianyang Mao (ORCID: https://orcid.org/0000-0001-9251-8592)
- Hannah Davis (ORCID: https://orcid.org/0000-0002-1245-2034)
- Aaron M. Ring (ORCID: https://orcid.org/0000-0003-3699-2446)
- Carolina Lucas (ORCID: https://orcid.org/0000-0003-4590-2756)
- Gina Assaf (ORCID: https://orcid.org/0000-0002-8149-0990)
- Lisa McCorkell (ORCID: https://orcid.org/0000-0002-3261-6737)
- Mitsuaki Sawano (ORCID: https://orcid.org/0000-0003-2789-1758)
- Takehiro Takahashi (ORCID: https://orcid.org/0000-0002-1061-356X)
- Mario A. Peña-Hernández
- César Caraballo (ORCID: https://orcid.org/0000-0002-4557-9437)
- Alexandra Tabachnikova (ORCID: https://orcid.org/0000-0003-4695-2480)
- Daisy Massey (ORCID: https://orcid.org/0000-0002-9922-7808)
- Athena Akrami (ORCID: https://orcid.org/0000-0001-5711-0903)
- Harlan M. Krumholz (ORCID: https://orcid.org/0000-0003-2046-127X)
- Diana Berrent Güthe
- Lan Xu (ORCID: https://orcid.org/0000-0002-9909-7660)
- Tiffany J. Tzeng
- Karen Harris (ORCID: https://orcid.org/0000-0002-5014-8404)
Institutions
- Yale New Haven Hospital (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Sainsbury Laboratory (GB)
- Yale University (US)
- Adaptive Biotechnologies (United States) (US)
- DCS Corporation (United States) (US)
- Patient-Led Research Collaborative
- University College London (GB)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1038/s43856-025-00829-3
- Citations
- 6
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Howard Hughes Medical Institute
- Yale University
- Center of Excellence in Regulatory Science and Innovation
- National Institute of Allergy and Infectious Diseases