Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type–Specific Risk Genes and Pathways Associated With Depression and Suicide
The distinct cell type-specific transcriptomic patterns, gene networks, and pathways reveal critical vulnerabilities associated with suicidality in individuals with MDD. These findings underscore the potential for targeted interventions aimed at these specific molecular pathways to mitigate suicide risk in individuals with depression.
Authors
- Aleena Francis (ORCID: https://orcid.org/0000-0001-9960-758X)
- Bhaskar Roy (ORCID: https://orcid.org/0000-0003-3604-6310)
- Yogesh Dwivedi (ORCID: https://orcid.org/0000-0002-5359-4717)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100530
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health