AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis
Despite the overall reduced brain volume compared to HC, distinct cortical regions, especially within the limbic system (i.e., cingulate gyrus and entorhinal area) GM may be relatively well preserved, indicating a possible compensatory volume increase. Based on this study, the corpus callosum is a crucial structure in monitoring disease progression in BRRMS.
Authors
- Juha Koikkalainen (ORCID: https://orcid.org/0000-0002-8406-3898)
- Marja Niiranen (ORCID: https://orcid.org/0000-0001-8674-020X)
- Eino Solje (ORCID: https://orcid.org/0000-0001-9940-9524)
- Tuomas A. Selander (ORCID: https://orcid.org/0000-0002-0070-8565)
- Päivi Hartikainen (ORCID: https://orcid.org/0000-0003-4081-9216)
- Ritva Vanninen (ORCID: https://orcid.org/0000-0003-2423-9350)
- Sakari Simula (ORCID: https://orcid.org/0000-0003-1623-5819)
- Peter Bendel
- Jyrki Lötjönen (ORCID: https://orcid.org/0000-0002-8698-4340)
- Anne M. Portaankorva
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- Moisio Hospital (FI)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fneur.2025.1570566
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- Suomen Kulttuurirahasto
- Kuopion Yliopistollinen Sairaala
- Maire Taposen Säätiö