Research Progress on Biomarkers of Sarcopenia in Maintenance Hemodialysis Patients

肌少症是一种进行性、全身性的骨骼肌疾病，主要表现为肌肉质量、力量和躯体功能的加速丧失，与不良结局的增加密切相关，包括跌倒、骨折、虚弱和死亡等。维持性血液透析患者受饮食限制、透析治疗和活动减少等因素的影响，肌肉流失加速，肌少症的发生率增加。本文通过查阅近年来国内外相关文献，对维持性血液透析患者肌少症的生物学标志物进行了一定的总结，旨在为临床早期识别并干预肌少症提供帮助，改善患者预后。Sarcopenia is a progressive, systemic skeletal muscle disease characterized by accelerated loss of muscle mass, strength, and somatic function and is strongly associated with increased adverse outcomes, including falls, fractures, weakness, and death. Maintenance hemodialysis patients suffer from accelerated muscle loss and an increased incidence of sarcopenia due to dietary restrictions, dialysis treatment, and reduced activity. In this paper, by reviewing the relevant literature at home and abroad in recent years, the biological markers of sarcopenia in maintenance hemodialysis patients have been summarized to some extent, aiming to provide help for the early identification and intervention of sarcopenia in the clinic and to improve the prognosis of patients.