Analysis of the Clinical Characteristics of Histiocytic Necrotizing Lymphadenitis in a Single Center

目的：回顾性分析组织细胞坏死性淋巴结炎(HNL)患者的临床特征，比较儿童组和成人组的差异，以拓展对本病的认识及诊断，减少漏诊、误诊率。方法：收集2010年1月至2024年6月年在空军军医大学第一附属医院住院的82例HNL患者的临床特征，包括一般资料、临床表现、辅助检查(包括全身炎症指标NLR、PLR、LMR、SII和SIRI)、淋巴结病理活检、治疗及预后，并比较分析儿童组(P = 0.001)、颈外淋巴结肿大(P = 0.021)、最大淋巴结直径(P = 0.049)、扁桃体肿大(P = 0.001)、肌肉关节疼痛(P = 0.023)、白蛋白减少(P = 0.01)、N (P = 0.042)、L (P P = 0.044)的差异存在统计学意义，在全身炎症指标NLR (P P P = 0.002)、SIRI (P P Objective: To retrospectively analyze the clinical characteristics of patients with histiocytic necrotizing lymphadenitis (HNL), compare the differences between the pediatric group and the adult group, and expand the understanding and diagnosis of this disease to reduce the rate of missed diagnosis and misdiagnosis. Methods: The clinical characteristics of 82 patients with HNL who were hospitalized at the First Affiliated Hospital of Air Force Military Medical University from January 2010 to June 2024 were collected, including general information, clinical manifestations, auxiliary examinations (including systemic inflammatory indicators NLR, PLR, LMR, SII and SIRI), lymph node pathological biopsy, treatment and prognosis. The differences in clinical characteristics between the pediatric group (P = 0.001), external cervical lymphadenopathy (P = 0.021), maximum lymph node diameter (P = 0.049), tonsillar hypertrophy (P = 0.001), muscle and joint pain (P = 0.023), decreased albumin (P = 0.01), N (P = 0.042), L (P P = 0.044). There were also statistically significant differences in systemic inflammatory indicators NLR (P P P = 0.002), SIRI (P P < 0.001). Conclusion: HNL is more common in male children and young women, with diverse and non-specific clinical manifestations and multiple infection sources. Whether these sources are related to the disease requires further research. Glucocorticoid treatment is effective, but there is a tendency for recurrence, and it can occur before or after SLE. Children are more likely to have tonsillar hypertrophy, decreased albumin, and neutropenia, while adults are more prone to cervical lymphadenopathy and muscle and joint pain. There are statistically significant differences in systemic inflammatory indicators between the pediatric and adult groups, but the impact on long-term quality of life remains to be further studied.