Research Advance on the Role of Endoplasmic Reticulum Stress in the Pathological Processes of Liver Diseases

肝脏疾病是临床上一类常见疾病，其发病机制与治疗策略的研究备受关注。众多研究显示内质网应激是肝脏疾病发生发展的重要机制，本文系统综述了内质网应激在酒精性肝病、代谢相关(非酒精性)脂肪性肝病、病毒性肝炎、肝纤维化、肝细胞癌及肝衰竭等肝脏疾病病理过程中的作用。Liver diseases are a common category of clinical conditions, and research into their pathogenesis and treatment strategies has attracted significant attention. Numerous studies have demonstrated that endoplasmic reticulum stress is a key mechanism in the development and progression of liver diseases. This article systematically reviews the role of endoplasmic reticulum stress in the pathological processes of various liver diseases, including alcoholic liver disease, metabolic dysfunction-associated (non-alcoholic) fatty liver disease, viral hepatitis, liver fibrosis, hepatocellular carcinoma, and liver failure.