Iron-Catalyzed Tunable Alkene Migratory Silylation and Transposition

The example of iron-catalyzed alkenes migratory silylation and transposition has been demonstrated, affording a tunable approach to synthesize thermodynamically stable allylsilanes and internal alkenes with high efficiency and regioselectivity. These reactions showcase several advantageous features, including good functional group tolerance, excellent regioselectivity, a broad substrate scope, scalability to gram-scale synthesis, and late-stage functionalization of bio-relevant molecules. Furthermore, the relay catalytic mechanism of the migratory silylation, involving both iron-silyl and iron-hydride intermediates, provides valuable insights into iron-catalyzed coupling reactions, opening new avenues for the development of novel transformations under iron catalysis.