Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids <i>via</i> an aromatization-driven deconstructive strategy
Dual-nickel/photoredox-catalyzed aromatization-mediated deconstruction and acylation of spiro-dihydroquinazolinones with carboxylic acids serving as acyl electrophiles is described. A series of synthetical ketone scaffolds with functional group tolerance could be obtained under mild conditions. A radical pathway involving an N-centered radical inducing β-scission to form a C-centered radical is proposed for these transformations.
Authors
- Wendian Li
- Jie Yang (ORCID: https://orcid.org/0009-0005-8817-6450)
- Kexin Huang (ORCID: https://orcid.org/0009-0000-7222-0262)
- Wenchao Gao (ORCID: https://orcid.org/0000-0002-6106-6287)
- Ting Li (ORCID: https://orcid.org/0000-0002-2186-6992)
- Wenguang Li (ORCID: https://orcid.org/0009-0003-4969-4621)
- Yong Teng
Institutions
- China Tobacco (CN)
- Nanyang Normal University (CN)
- Nanyang Institute of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01289a
- Citations
- 9
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 8.42
Funders
- National Natural Science Foundation of China