Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis
In summary, our study systematically demonstrated the role of gut-heart axis in NPs-induced cardiac injury, and the specific process was that NPs exposure reduced propionate level, which in turn inhibited FBP1 expression to impair cardiac function. These findings provide new insights into NPs-induced cardiotoxicity and identifie potential therapeutic targets, providing clues for the prevention and treatment of NPs-induced cardiac injury in the future.
Authors
- Guangyu Jiang (ORCID: https://orcid.org/0000-0003-1141-1019)
- Danyang Huang (ORCID: https://orcid.org/0000-0002-4053-2680)
- Ai Gao (ORCID: https://orcid.org/0000-0002-0764-4656)
- Wei Zhang (ORCID: https://orcid.org/0009-0006-6821-1420)
- Jingyu Wang (ORCID: https://orcid.org/0000-0003-1453-9587)
- Ziyan Liu (ORCID: https://orcid.org/0000-0002-0282-7314)
- Huiwen Kang
- Ziyan Wang (ORCID: https://orcid.org/0000-0002-0424-4606)
Institutions
- Capital Medical University (CN)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12989-025-00626-9
- Citations
- 4
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China