Modeling Studies of Microtubule Polymerization Promoted by Kinesin‐5 Motors

ABSTRACT Kinesin‐5 Eg5 motors have the ability to promote microtubule polymerization. However, how the Eg5 motors can promote the microtubule polymerization is unclear. Here, a model is presented, based on which the dynamics of the microtubule polymerization promoted by the Eg5 motors is studied analytically. For comparison, the dynamics of the microtubule polymerization in the presence of kinesin‐1 motors and in the absence of the kinesin motor is also studied analytically. The analytical results explain quantitatively the available experimental data. The predicted results are also provided.

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Publication Details

Journal
Applied Research
Published
2025-05-09
DOI
https://doi.org/10.1002/appl.70017
Primary Topic
Microtubule and mitosis dynamics
Type
article
Field-Weighted Citation Impact
0.00
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article

Modeling Studies of Microtubule Polymerization Promoted by Kinesin‐5 Motors

Ping Xie
Applied Research
Microtubule and mitosis dynamics
article

Modeling Studies of Microtubule Polymerization Promoted by Kinesin‐5 Motors

Ping Xie
article en

Abstract

ABSTRACT Kinesin‐5 Eg5 motors have the ability to promote microtubule polymerization. However, how the Eg5 motors can promote the microtubule polymerization is unclear. Here, a model is presented, based on which the dynamics of the microtubule polymerization promoted by the Eg5 motors is studied analytically. For comparison, the dynamics of the microtubule polymerization in the presence of kinesin‐1 motors and in the absence of the kinesin motor is also studied analytically. The analytical results explain quantitatively the available experimental data. The predicted results are also provided.

Applied ResearchVol. 4(3)
Institute of Physics (CN)
Openalex Percentile: Top 89%
Microtubule and mitosis dynamics
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