Multidimensional metabolic engineering of <i>Yarrowia lipolytica</i> for highly efficient biosynthesis of betulinic acid
Yarrowia lipolytica was engineered for high-level betulinic acid production via modular pathway and organelle engineering, precursor and redox optimization, metabolic rewiring, and 3 L fermentation using cost-effective carbon sources.
Authors
- Y.S. Li
- Liangcheng Jiao
- Jinyong Yan (ORCID: https://orcid.org/0000-0003-2543-203X)
- Yunjun Yan (ORCID: https://orcid.org/0000-0001-6643-597X)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0002-1738-9329)
- Guowei Zhao (ORCID: https://orcid.org/0009-0007-3595-2772)
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Green Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5gc01276g
- Citations
- 7
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 5.64