Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF

Together, these findings underscore the pivotal role of mitochondrial dysfunction in HFpEF pathogenesis, implicating both NNT and Fgf1 as novel therapeutic targets.

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Publication Details

Journal
Circulation Research
Published
2025-05-09
DOI
https://doi.org/10.1161/circresaha.125.326154
Citations
15
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
20.82
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article

Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF

Alexander Nickel, Joshua Gorham, Christine E. Seidman, Norbert Frey et al.
15 citations
Circulation Research
Cardiovascular Function and Risk Factors
20.82
article

Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF

Alexander Nickel, Joshua Gorham, Christine E. Seidman, Norbert Frey, Adriano B. Chaves‐Filho, Jonathan G. Seidman, Matthias Dewenter, Friederike Schreiter, Christoph Maack, Mathias Hohl, Mark E. Pepin, Philipp J.M. Konrad, Anja Karlstaedt, Johannes Backs, Almut Schulze, Farhad Bazgir, Sumra Nazir
article en
15 citations

Abstract

Together, these findings underscore the pivotal role of mitochondrial dysfunction in HFpEF pathogenesis, implicating both NNT and Fgf1 as novel therapeutic targets.

Circulation ResearchVol. 136(12)
Broad Institute (US), Helmholtz Association of German Research Centres (DE), Harvard University (US), German Cancer Research Center (DE), Max Delbrück Center (DE), Heidelberg University (DE), Cardiovascular Institute of the South (US), University Hospital Heidelberg (DE), Comprehensive Cancer Center Mainfranken (DE), Universitätsklinikum Würzburg (DE), German Centre for Cardiovascular Research (DE), European Molecular Biology Laboratory (DE), Cedars-Sinai Smidt Heart Institute (US), European Molecular Biology Laboratory (DE), Saarland University (DE)
Good health and well-being
Openalex Percentile: Top 0%
Cardiovascular Function and Risk Factors
20.82
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