Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF
Together, these findings underscore the pivotal role of mitochondrial dysfunction in HFpEF pathogenesis, implicating both NNT and Fgf1 as novel therapeutic targets.
Authors
- Alexander Nickel (ORCID: https://orcid.org/0000-0002-2562-0439)
- Joshua Gorham (ORCID: https://orcid.org/0000-0001-5969-4690)
- Christine E. Seidman (ORCID: https://orcid.org/0000-0001-6380-1209)
- Norbert Frey (ORCID: https://orcid.org/0000-0001-7611-378X)
- Adriano B. Chaves‐Filho (ORCID: https://orcid.org/0000-0002-2321-6504)
- Jonathan G. Seidman (ORCID: https://orcid.org/0000-0002-9082-3566)
- Matthias Dewenter (ORCID: https://orcid.org/0000-0003-1335-4820)
- Friederike Schreiter
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Mathias Hohl (ORCID: https://orcid.org/0000-0001-6946-9825)
- Mark E. Pepin (ORCID: https://orcid.org/0000-0003-0114-560X)
- Philipp J.M. Konrad (ORCID: https://orcid.org/0009-0003-1522-3848)
- Anja Karlstaedt (ORCID: https://orcid.org/0000-0001-5689-3571)
- Johannes Backs (ORCID: https://orcid.org/0000-0002-2322-2699)
- Almut Schulze (ORCID: https://orcid.org/0000-0002-8199-6422)
- Farhad Bazgir (ORCID: https://orcid.org/0000-0002-0689-7926)
- Sumra Nazir
Institutions
- Broad Institute (US)
- Helmholtz Association of German Research Centres (DE)
- Harvard University (US)
- German Cancer Research Center (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Cardiovascular Institute of the South (US)
- University Hospital Heidelberg (DE)
- Comprehensive Cancer Center Mainfranken (DE)
- Universitätsklinikum Würzburg (DE)
- German Centre for Cardiovascular Research (DE)
- European Molecular Biology Laboratory (DE)
- Cedars-Sinai Smidt Heart Institute (US)
- European Molecular Biology Laboratory (DE)
- Saarland University (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1161/circresaha.125.326154
- Citations
- 15
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 20.82