Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
We show here that single-molecule sequencing enables unbiased detection and characterization of DNA replication initiation events, including the numerous dispersed initiation events that replicate most of the human genome.
Authors
- Jamie T. Carrington (ORCID: https://orcid.org/0000-0001-5437-1921)
- Rosemary H. C. Wilson (ORCID: https://orcid.org/0000-0003-3865-6729)
- Tom Barker
- Conrad A. Nieduszynski (ORCID: https://orcid.org/0000-0003-2001-076X)
- Karim Gharbi (ORCID: https://orcid.org/0000-0003-1092-4488)
- Eleazar Miera Saenz de Vega
- Christopher B. Watkins (ORCID: https://orcid.org/0000-0003-3667-2442)
- Leah Catchpole (ORCID: https://orcid.org/0009-0003-6498-6892)
- Alex Durrant (ORCID: https://orcid.org/0009-0002-7230-6124)
- Sathish Thiyagarajan (ORCID: https://orcid.org/0000-0001-8545-8886)
- Vanda Knitlhoffer (ORCID: https://orcid.org/0009-0002-5230-6936)
Institutions
- Norwich Research Park (GB)
- University of Oxford (GB)
- Earlham Institute (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13059-025-03591-w
- Citations
- 10
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- Wellcome Trust
- UK Research and Innovation
- University of Oxford
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council