Treatment of post-traumatic brain injury using high-dose neurotrophic factors – a case report study

Introduction. Post-traumatic brain injury (TBI) dementia is a serious neurodegenerative condition, with or without behavioral disturbances, that can dramatically change the quality of life of both patients and their caretakers, and without an available effective treatment, the prognosis of these patients is not favorable. Objective. The purpose of this case report study was to present the effects of the porcine brain-derivate hydrolysate (PBDH) in a severe case of post-TBI dementia and the gradual improvement of symptoms based on cognitive function tests. Methodology. A high-dose regimen of neurotrophic factors was initiated, consisting of PDBH 30 mL/administration, 10 days/month, for three months, while the treatment efficacy was monitored using the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Global Assessment of Functioning Scale (GAFS). Conclusions. Following the completion of the PBDH regimen, the patient registered an improvement in the cognitive function, from severe impairment to moderate impairment, and in the functionality as well. The same regimen will be repeated three months later to maintain or improve the current results, which reflected the efficacy of PBDH in post-TBI dementia.