Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations
In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.
Authors
- Wilbert Zwart (ORCID: https://orcid.org/0000-0002-9823-7289)
- Karianne Schuurman (ORCID: https://orcid.org/0000-0002-9278-0571)
- Sebastian Gregoricchio (ORCID: https://orcid.org/0000-0001-9209-5403)
- Tesa Severson (ORCID: https://orcid.org/0000-0002-7568-4705)
- Lodewyk F.A. Wessels (ORCID: https://orcid.org/0000-0002-1656-6995)
- Aleksandar Kojić (ORCID: https://orcid.org/0000-0002-3987-3699)
- Dylan M. Glubb
- Suzan Stelloo (ORCID: https://orcid.org/0000-0002-6696-836X)
- Flora E. van Leeuwen (ORCID: https://orcid.org/0000-0002-5871-1484)
- Marjolein Droog
- Marlous Hoogstraat (ORCID: https://orcid.org/0000-0002-4916-1177)
- Abhishek A. Singh (ORCID: https://orcid.org/0000-0003-0577-3451)
- Michiel Vermeulen (ORCID: https://orcid.org/0000-0003-0836-6894)
- Tracy A. O’Mara (ORCID: https://orcid.org/0000-0002-5436-3232)
Institutions
- Radboud University Nijmegen (NL)
- QIMR Berghofer Medical Research Institute (AU)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13059-025-03596-5
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Oncode Institute
- Medical Research Council
- National Health and Medical Research Council