Parent-of-origin regulation by maternal auts2 shapes neurodevelopment and behavior in fish
Together, our results reveal the unsuspected role of an autism-related gene expressed in the mother's oocyte in shaping progeny neurodevelopment and behavior. Finally, we report that auts2a/AUTS2 is part of a group of evolutionarily conserved genes associated with human neurodevelopmental disorders and expressed in oocytes across species, from fish to mammals. These findings raise important questions about their potential role in the non-genetic regulation of progeny neurodevelopment and behavior in vertebrates.
Authors
- Constance Merdrignac (ORCID: https://orcid.org/0000-0003-3421-1546)
- Jérôme Montfort (ORCID: https://orcid.org/0000-0002-2777-0246)
- Sergi Roig‐Puiggros (ORCID: https://orcid.org/0000-0001-5909-218X)
- Antoine Emile Clément (ORCID: https://orcid.org/0000-0001-5966-4619)
- Alexandra Dauvé
- Violaine Colson (ORCID: https://orcid.org/0000-0003-0934-7935)
- Amaury Herpin (ORCID: https://orcid.org/0000-0002-0630-4027)
- Florent Murat (ORCID: https://orcid.org/0000-0003-2116-2511)
- Aurélien Brionne (ORCID: https://orcid.org/0009-0009-3301-3813)
- Denis Jabaudon (ORCID: https://orcid.org/0000-0003-2438-4769)
- Julien Bobe (ORCID: https://orcid.org/0000-0002-9355-8227)
- Cervin Guyomar (ORCID: https://orcid.org/0000-0003-2707-2541)
- Thomas Lafond
- Thaovi Nguyen
- Dorine Sévère
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- École Nationale Vétérinaire de Toulouse (FR)
- Université de Montpellier (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Montpellier GenomiX (FR)
- Laboratoire de Physiologie et Génomique des Poissons (FR)
- Génétique Physiologie et Systèmes d'Elevage (FR)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13059-025-03600-y
- Citations
- 1
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Agence Nationale de la Recherche
- Région Bretagne
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement