Delineating the Significance of Several Inflammatory Markers in a Lung Tuberculosis Cohort During the Active and Post-Tuberculosis Stages of the Disease: An Observational Study in Cape Town, South Africa (2019 to 2024)
These inflammatory biomarkers correlated well with lung function in the post-TB state, and their high levels suggest a persistent pro-inflammatory state post-TB, which may contribute to post-TB lung disease. More research is warranted to better understand this phenomenon, but these findings may highlight a need to consider anti-inflammatory therapy for patients with post-TB lung disease, especially since these high levels of cytokines can directly contribute to lung damage.
Authors
- B. Botha
- Olakunle Sanni (ORCID: https://orcid.org/0000-0002-4924-9005)
- Sigrid Schulz
- Shantal Windvogel (ORCID: https://orcid.org/0000-0001-8108-715X)
- Carmen Payne (ORCID: https://orcid.org/0000-0002-3361-0214)
- Chrisstoffel Jumaar (ORCID: https://orcid.org/0000-0002-8070-5021)
- Merga Belina Feyasa (ORCID: https://orcid.org/0000-0001-5862-5941)
- Gerald J. Maarman (ORCID: https://orcid.org/0000-0003-3336-5594)
- David Maree
- Brian Allwood (ORCID: https://orcid.org/0000-0003-0421-2978)
- Hans Strijdom (ORCID: https://orcid.org/0000-0003-3726-9153)
- Steve Jacobs (ORCID: https://orcid.org/0000-0001-5674-252X)
- Nicola Baines (ORCID: https://orcid.org/0009-0004-1165-0858)
- Carl Lombard (ORCID: https://orcid.org/0000-0002-2136-6533)
- Lindiwe Malefane (ORCID: https://orcid.org/0000-0003-1342-0584)
- Elizabeth H. Louw (ORCID: https://orcid.org/0000-0003-4385-2249)
Institutions
- South African Medical Research Council (ZA)
- Stellenbosch University (ZA)
- Tygerberg Hospital (ZA)
- Addis Ababa University (ET)
Publication Details
- Journal
- Infectious Disease Reports
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3390/idr17030052
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- South African Medical Research Council