Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study
Treatment with simvastatin-NP significantly reduced volume and weight of adenomyosis xenografts while attenuating Ki67 expression when compared to the control and simvastatin groups. <b><i>Conclusions:</i></b> This pilot study demonstrates promising improved efficacy of simvastatin delivered via liposomal nanoparticles. However, larger studies are needed to fully explore the potential of simvastatin-NP in adenomyosis.
Authors
- Jamal I. Saada (ORCID: https://orcid.org/0000-0001-9550-9704)
- Jinping Yang (ORCID: https://orcid.org/0000-0002-9791-4751)
- Mostafa A. Borahay (ORCID: https://orcid.org/0000-0002-0554-132X)
- Massoud Motamedi (ORCID: https://orcid.org/0000-0003-0733-2588)
- Kathleen L. Vincent (ORCID: https://orcid.org/0000-0003-3051-9551)
- Bülent Özpolat (ORCID: https://orcid.org/0000-0001-8602-7463)
- Gökhan S. Kılıç (ORCID: https://orcid.org/0000-0002-7926-7458)
- Gregory W. Kirschen (ORCID: https://orcid.org/0000-0003-1371-8137)
- Rachel Michel (ORCID: https://orcid.org/0009-0002-4591-8168)
Institutions
- Houston Methodist (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- The University of Texas Medical Branch at Galveston (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of Obstetrics and Gynaecology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1080/01443615.2025.2502083
- Citations
- 2
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences