Fat mass and obesity-associated protein downregulation trigger the activation of the sirtuin 1/forkhead box O1 signaling pathway, drive glycolysis, and promote the progression of renal cell carcinoma
FTO downregulation promotes glycolysis and proliferation in RCC cells by activating the SIRT1/ FOXO1 signaling pathway. Targeting the FTO and SIRT1/FOXO1 pathway may provide potential therapeutic strategies for the treatment of RCC.
Authors
- Ren-Zhong Zhang
- Zheng Zhang (ORCID: https://orcid.org/0000-0002-8438-1829)
- Jifeng Zhang (ORCID: https://orcid.org/0000-0002-7804-7437)
Institutions
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2025-05-09
- DOI
- https://doi.org/10.25259/cytojournal_33_2025
- Citations
- 2
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04