Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures
Abstract Urethral strictures caused by injury, infection, or inflammation present significant clinical challenges, often leading to severe complications such as kidney failure and infertility. A novel spatiotemporal theragenerative platform, the Joule‐assisted nanotherapeutic urethral stent (JANUS), is designed in this study to treat urethral strictures and promote urothelial regeneration. This platform uses a biodegradable magnesium (Mg) alloy stent dual coated with thermoresponsive polycaprolactone (TRP) and sirolimus nanoparticles (nSRL). The dual‐sided coating is optimized for distinct therapeutic and regenerative functions. External magnetic stimuli induce localized hyperthermia via Joule heating, facilitate a controlled nSRL release from the TRP coating, enhance bacterial ablation, and inhibit smooth muscle cell proliferation. Simultaneously, Mg ions released from the stent promote endothelial cell proliferation. JANUS demonstrates significant potential as an effective theragenerative platform, offering a balanced therapy and tissue regeneration approach in treating urethral strictures.
Authors
- Soo‐Hong Lee (ORCID: https://orcid.org/0000-0001-6369-8301)
- Chan Ho Moon
- Yubeen Park (ORCID: https://orcid.org/0000-0001-8223-2339)
- Hyun‐Do Jung (ORCID: https://orcid.org/0000-0001-8632-7431)
- Yuhyun Na
- Wooram Park (ORCID: https://orcid.org/0000-0002-4614-0530)
- Heemin Kang (ORCID: https://orcid.org/0000-0003-2694-9882)
- Jung‐Hoon Park (ORCID: https://orcid.org/0000-0001-9114-7750)
- Hyun Lee (ORCID: https://orcid.org/0000-0001-8495-5047)
- Min‐Ho Kang (ORCID: https://orcid.org/0000-0002-1342-0077)
- Hyeong Seok Kang (ORCID: https://orcid.org/0000-0002-4839-9861)
- Jeong Hyun Seo
- Gi Doo (ORCID: https://orcid.org/0000-0002-4771-3396)
- Seokhwan Bang (ORCID: https://orcid.org/0000-0003-1232-0688)
- Song Hee Kim (ORCID: https://orcid.org/0000-0001-5412-6096)
- Ju Yeong Gwon
Institutions
- Ulsan College (KR)
- Korea University (KR)
- Dongguk University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Hanyang University (KR)
- Chung-Ang University (KR)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
- Korea Institute of Industrial Technology (KR)
- Anyang University (KR)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1002/adfm.202416694
- Citations
- 10
- Primary Topic
- Urological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 18.37
Funders
- National Research Foundation of Korea
- Korea Institute of Marine Science and Technology promotion