Photocatalytic Dual-Defluorination Thiolation of Trifluoromethyl Hydrazones
The defluorination of trifluoromethyl groups typically involves breaking one or all three C-F bonds, while selectively cleaving exactly two C-F bonds presents a considerable challenge. In this work, we present a method for the sequential defluorination of trifluoromethyl hydrazones under photocatalytic conditions, which involves the specific breakage of two C-F bonds followed by thiolation to yield monofluorinated alkenes containing a thiol group. Transforming trifluoromethyl-containing polyfluoroalkyl substances into fluorinated non-PFAS compounds holds potential practical implications.
Authors
- Jin‐Hong Lin (ORCID: https://orcid.org/0000-0002-7000-9540)
- Wenjie Pan (ORCID: https://orcid.org/0000-0003-4084-6222)
- Weiguo Cao (ORCID: https://orcid.org/0000-0002-6482-2877)
- Ji‐Chang Xiao (ORCID: https://orcid.org/0000-0001-8881-1796)
Institutions
- Shanghai University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Innovative Research (United States) (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01492
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China