Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology
Our findings revealed shared and distinct pathways underlying psychopathology. Integrating genomic insights with the RDoC and HiTOP frameworks advanced our understanding of mechanisms that underlie EXT and INT psychopathology.
Authors
- Daniel F. Levey (ORCID: https://orcid.org/0000-0001-8431-9569)
- Yousef Khan (ORCID: https://orcid.org/0009-0002-3093-3947)
- Christal N. Davis (ORCID: https://orcid.org/0000-0003-3974-5598)
- Joel Gelernter (ORCID: https://orcid.org/0000-0002-4067-1859)
- Rachel L. Kember (ORCID: https://orcid.org/0000-0001-8820-2659)
- Sylvanus Toikumo (ORCID: https://orcid.org/0000-0002-6024-0693)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Dorret Irene Boomsma (ORCID: https://orcid.org/0000-0002-7099-7972)
- Zeal Jinwala (ORCID: https://orcid.org/0009-0005-5062-0827)
Institutions
- Yale University (US)
- VA Connecticut Healthcare System (US)
- Amsterdam Neuroscience (NL)
- Cognitive Research (United States) (US)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725000819
- Citations
- 2
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- U.S. Department of Veterans Affairs
- Koninklijke Nederlandse Akademie van Wetenschappen
- National Institute on Alcohol Abuse and Alcoholism