Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses
Results of this case-control study suggest that individuals with high ADHD-PRS and/or low educational attainment-PRS had an associated elevated risk of CM. Extra attention should be given to individuals at high risk for CM across all 5 psychiatric diagnoses, ie, females with a high ADHD-PGS and/or a parent diagnosed with a psychiatric disorder.
Authors
- Trine Tollerup Nielsen (ORCID: https://orcid.org/0009-0005-4014-8880)
- Ditte Demontis (ORCID: https://orcid.org/0000-0001-9124-2766)
- Søren Dalsgaard (ORCID: https://orcid.org/0000-0003-4659-0969)
- Richard Anney (ORCID: https://orcid.org/0000-0002-6083-407X)
- Ludger Tebartz van Elst (ORCID: https://orcid.org/0000-0002-2274-5447)
- Anders D. Børglum (ORCID: https://orcid.org/0000-0001-8627-7219)
- Tinca J. C. Polderman (ORCID: https://orcid.org/0000-0001-5564-301X)
- Paraskevi Bali (ORCID: https://orcid.org/0000-0002-0734-4952)
- Christina Mohr Jensen (ORCID: https://orcid.org/0000-0002-6055-7228)
- Stephen W. Scherer (ORCID: https://orcid.org/0000-0002-8326-1999)
- Jakob Grove (ORCID: https://orcid.org/0000-0003-2284-5744)
- Melanie M. de Wit (ORCID: https://orcid.org/0000-0002-7318-6155)
- Edmund Sonuga‐Barke (ORCID: https://orcid.org/0000-0002-6996-3935)
- Thomas Bourgeron (ORCID: https://orcid.org/0000-0001-8164-9220)
- Elizabeth C. Corfield (ORCID: https://orcid.org/0000-0002-0119-157X)
- Manuel Mattheisen (ORCID: https://orcid.org/0000-0002-8442-493X)
- Mohammed Jashim Uddin
- Thomas Werge
- Helen Minnis
Institutions
- Broad Institute (US)
- University of Copenhagen (DK)
- Dalhousie University (CA)
- Norwegian Institute of Public Health (NO)
- Institut Pasteur (FR)
- University of Freiburg (DE)
- King's College London (GB)
- University of Toronto (CA)
- Aarhus University (DK)
- Aalborg University Hospital (DK)
- Mental Health Services (DK)
- Hospital for Sick Children (CA)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Foundation Center (US)
- Genome Canada (CA)
- Karolinska Institutet (SE)
- Lovisenberg Diakonale Høgskole (NO)
- Novo Nordisk (United States) (US)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Lundbeck Foundation (DK)
- Capital Region of Denmark (DK)
- Amsterdam University Medical Centers (NL)
- University of Glasgow (GB)
- Cardiff University (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Hong Kong (HK)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.0828
- Citations
- 6
- Primary Topic
- Child Abuse and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 13.84
Funders
- Amsterdam University Medical Centers
- Cardiff University
- University of Toronto
- Hospital for Sick Children