Evaluation of the Genotoxicity and Cytotoxicity of Bioceramic Endodontic Sealers in HepG2 and V79 Cell Lines: An In Vitro Study Using the Comet and Micronucleus Assays
The findings suggest that MTA Fillapex and BioRoot RCS exhibit superior biocompatibility over AH Plus, as evidenced by their lower cytotoxic and genotoxic effects in vitro. These results support the use of calcium silicate-based sealers in clinical practice, highlighting the need for further studies to evaluate their performance in vivo and their implications for patient safety.
Authors
- Danijela Jurić Kaćunić
- Ivan Kovačić (ORCID: https://orcid.org/0000-0003-4971-471X)
- Antonija Tadin (ORCID: https://orcid.org/0000-0002-5365-9816)
- Davor Želježić (ORCID: https://orcid.org/0000-0002-8214-0212)
- Matea Macan (ORCID: https://orcid.org/0000-0003-4532-7368)
- Marija Badrov (ORCID: https://orcid.org/0009-0008-3637-7770)
- Nada Galić
Institutions
- University Hospital Centre Zagreb (HR)
- University of Zagreb (HR)
- Klinički Bolnički Centar Split (HR)
- Institute for Medical Research and Occupational Health (HR)
- University of Split (HR)
Publication Details
- Journal
- Journal of Functional Biomaterials
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3390/jfb16050169
- Citations
- 1
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.79