Double fluorescence-guided surgery with 5-ALA and fluorescein sodium in grade 2 and grade 3 adult-type diffuse gliomas: retrospective analysis of 112 cases
The results achieved in this study do not support the role of 5-ALA and FS to intraoperatively define the extent of resection, because of low fluorescence rates. Nevertheless, 5-ALA expression could be used to intraoperatively identify more aggressive foci and add useful prognostic information before the histological analysis. Indeed, FS is mostly related to blood-brain barrier damage and, thus, with contrast enhancement in MRI.
Authors
- Marta Bonada
- Antonio Melcarne (ORCID: https://orcid.org/0000-0002-1925-2641)
- Pietro Zeppa (ORCID: https://orcid.org/0000-0002-8649-3621)
- Francesco Bruno (ORCID: https://orcid.org/0000-0001-8087-5293)
- Diego Garbossa (ORCID: https://orcid.org/0000-0002-2692-7133)
- Andrea Bianconi (ORCID: https://orcid.org/0000-0002-1014-0731)
- Fabio Cofano (ORCID: https://orcid.org/0000-0002-5100-7478)
- Roberta Rudà (ORCID: https://orcid.org/0000-0001-9134-1537)
- Pietro La Cava
- Flavio Panico
Institutions
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
Publication Details
- Journal
- Brain and Spine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.bas.2025.104277
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63