Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites

This study identified that specific immune cell phenotypes directly influence glioma risk and indirectly modulate this risk through cerebrospinal fluid metabolites. CD19 on IgD( +) CD24(-) B cells were identified as risk factors, while CD11c on monocytes were protective. Metabolites like 7-hoca and glycerophosphoinositol play key mediating roles. These findings enhance our understanding of glioma pathophysiology and suggest that immune modulation and metabolic intervention may be promising therapeutic strategies.