Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, inhibits adrenal aldosterone synthesis and renal ERK/EGR1 pathway in the treatment of diabetic kidney disease
The present study reveals a novel pharmaceutical role of A. manihot (L.) in the treatment of DKD via suppressing the aldosterone-ERK/EGR1 pathway, and MR activation, thereby reducing the fibrosis and kidney dysfunction.
Authors
- Haitao Ge
- Harvest F. Gu (ORCID: https://orcid.org/0000-0003-4578-5449)
- Rengui Saxu
- Haitao Tang (ORCID: https://orcid.org/0000-0001-7531-0458)
- Hongmei Yu (ORCID: https://orcid.org/0000-0002-8279-7513)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jep.2025.119936
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29