Rhythm control benefits left ventricular function compared with rate control in patients with atrial fibrillation: A computational study
Rhythm control provides superior improvements in LV function compared with rate control. However, restoring sinus rhythm may yield limited benefits to LV function when atrial contraction is ineffective or when heart rate is irregular.
Authors
- Steven Niederer (ORCID: https://orcid.org/0000-0002-4612-6982)
- Gernot Plank (ORCID: https://orcid.org/0000-0002-7380-6908)
- José Alonso Solís-Lemus (ORCID: https://orcid.org/0000-0002-2596-7811)
- Christoph M. Augustin (ORCID: https://orcid.org/0000-0001-6341-4014)
- Matthias A. F. Gsell (ORCID: https://orcid.org/0000-0001-7742-8193)
- Martin J. Bishop (ORCID: https://orcid.org/0000-0002-6237-1902)
- Rosie K. Barrows (ORCID: https://orcid.org/0000-0001-7155-9483)
- John Whitaker (ORCID: https://orcid.org/0000-0002-5361-5725)
- Alistair A. Young (ORCID: https://orcid.org/0000-0001-5702-4220)
- Caroline H. Roney (ORCID: https://orcid.org/0000-0001-6809-0928)
- Edward J. Vigmond (ORCID: https://orcid.org/0000-0003-1388-3589)
- Ronak Rajani (ORCID: https://orcid.org/0000-0002-8816-6296)
- Marina Strocchi (ORCID: https://orcid.org/0000-0003-1312-251X)
- Hao Xu (ORCID: https://orcid.org/0000-0001-6459-1063)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Queen Mary University of London (GB)
- King's College London (GB)
- Medical University of Graz (AT)
- Graz University of Technology (AT)
- Electrophysiology and Heart Modeling Institute (FR)
- BioTechMed-Graz (AT)
- The Alan Turing Institute (GB)
- Institut Polytechnique de Bordeaux (FR)
- Institut de Mathématiques de Bordeaux (FR)
- Imperial College London (GB)
Publication Details
- Journal
- Heart Rhythm O2
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.hroo.2025.04.014
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alan Turing Institute
- National Institute for Health and Care Research
- British Heart Foundation
- Agence Nationale de la Recherche
- Austrian Science Fund
- National Institutes of Health
- Engineering and Physical Sciences Research Council
- European Research Council
- NIHR Imperial Biomedical Research Centre