Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target
Despite the small sample size, these findings suggest potential age-related molecular mechanisms and highlight candidate genes for further investigation as novel therapeutic targets. Notably, we identified CDK9 as a promising target, warranting further exploration in the context of ARMS treatment.
Authors
- Barbara Mancini
- Isabella Giovannoni (ORCID: https://orcid.org/0000-0002-9980-6594)
- Lucia Pedace (ORCID: https://orcid.org/0000-0001-8552-3641)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Luana Abballe (ORCID: https://orcid.org/0000-0003-4446-2293)
- Angela Di Giannatale (ORCID: https://orcid.org/0000-0001-8465-3612)
- Ida Russo (ORCID: https://orcid.org/0000-0002-7030-8639)
- Matteo Cassandri (ORCID: https://orcid.org/0000-0002-2919-676X)
- Rossella Rota (ORCID: https://orcid.org/0000-0002-9408-7711)
- Silvia Vallese (ORCID: https://orcid.org/0000-0001-6342-065X)
- Celeste Antonacci (ORCID: https://orcid.org/0000-0003-2872-5401)
- Sabina Barresi (ORCID: https://orcid.org/0000-0002-7307-388X)
- Giuseppe Maria Milano (ORCID: https://orcid.org/0000-0002-0250-6043)
- Sara Patrizi (ORCID: https://orcid.org/0000-0003-1898-1516)
- Alessandra Stracuzzi (ORCID: https://orcid.org/0000-0002-7762-196X)
- Rita Alaggio
- Evelina Miele
- Flavia Vinciarelli
Institutions
- Bambino Gesù Children's Hospital (IT)
Publication Details
- Journal
- Pharmacological Research
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.phrs.2025.107767
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Ministero della Salute
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro