Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion
Our study uncovers a novel mechanism in which Kcnma1 deletion in HSCs enhances AREG secretion, thereby reducing lipid accumulation in hepatocytes through the AREG/EGFR signaling, ultimately inhibiting the progression of MASLD.
Authors
- Sheng Cheng (ORCID: https://orcid.org/0000-0002-4526-9009)
- Xirong Guo (ORCID: https://orcid.org/0000-0003-4873-8832)
- Jiaoxiang Wu (ORCID: https://orcid.org/0000-0002-2309-4164)
- Y. Li (ORCID: https://orcid.org/0009-0008-1080-7787)
- Peng Sun (ORCID: https://orcid.org/0000-0003-4424-5969)
- Shangwei Hou (ORCID: https://orcid.org/0000-0002-5958-7198)
- Xianbin Su (ORCID: https://orcid.org/0000-0001-5705-6062)
- Qiyu Bao (ORCID: https://orcid.org/0000-0002-9550-8266)
- Tianhui Chen (ORCID: https://orcid.org/0000-0003-4677-0361)
- Man Zhang (ORCID: https://orcid.org/0009-0005-6209-2822)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-4298-7926)
- Li Tang (ORCID: https://orcid.org/0000-0002-6246-4391)
- Y Liu (ORCID: https://orcid.org/0009-0009-0402-2016)
- Bo Han (ORCID: https://orcid.org/0000-0002-9882-7166)
- Yunhan Zou
- Daqing Cheng
- Jin Zhang (ORCID: https://orcid.org/0000-0003-3554-2996)
Institutions
- Guizhou University (CN)
- Shanghai Jiao Tong University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Tongren Hospital (CN)
- Guiyang University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.molmet.2025.102164
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35