Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway
<i>Polygonatum sibiricum</i> polysaccharides protects pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative stress and apoptosis via AMPK-SIRT1 pathway activation. Network pharmacology and molecular docking further highlight PSP's potential as a multi-target therapeutic agent for diabetes.
Authors
- Shuyao Tang
- Shaowu Cheng (ORCID: https://orcid.org/0000-0001-9059-4727)
- Zhenyan Song (ORCID: https://orcid.org/0000-0003-0758-7484)
- Lin Fan (ORCID: https://orcid.org/0000-0002-9411-496X)
- Liya Huang (ORCID: https://orcid.org/0000-0002-5940-4195)
- Yingshi Ouyang (ORCID: https://orcid.org/0000-0002-8970-1297)
- Ping Li (ORCID: https://orcid.org/0000-0002-3689-8807)
- Wenjing Yu (ORCID: https://orcid.org/0000-0003-0972-8172)
- Di Wu (ORCID: https://orcid.org/0000-0002-9001-139X)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3389/fnut.2025.1601490
- Citations
- 5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 10.03