A mitochondria‐targeting and G‐quadruplex structure‐binding ligand inducing calcium overload and ferroptosis in human cancer cells
BYB, via targeting mitochondria and mtDNA G-quadruplexes, induced mitochondrial calcium overload and ferroptosis, exhibited high in vivo antitumour efficacy and low toxicity. It shows high potential to be a mitochondria-targeting lead compound for chemical biology and drug discovery.
Authors
- Wei Long
- Yaoxun Zeng
- Mengting She
- Bo‐Xin Zheng (ORCID: https://orcid.org/0009-0001-0191-9719)
- Wing‐Leung Wong (ORCID: https://orcid.org/0000-0001-7191-7578)
- Chun‐Ming Chan (ORCID: https://orcid.org/0000-0003-3859-8477)
- Yingying Zheng (ORCID: https://orcid.org/0009-0000-2814-0273)
- Wende Zheng (ORCID: https://orcid.org/0009-0003-3747-6352)
- Yu‐Jing Lu (ORCID: https://orcid.org/0000-0003-2494-843X)
- Alan Siu‐Lun Leung
- Yakun Wang (ORCID: https://orcid.org/0000-0002-5880-172X)
- Ka‐Hin Chan
Institutions
- Guangdong University of Technology (CN)
- Hong Kong Polytechnic University (HK)
- Shenzhen Polytechnic University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1111/bph.70061
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Hong Kong Polytechnic University
- Guangdong University of Technology
- Basic and Applied Basic Research Foundation of Guangdong Province