Metformin aggravates pancreatitis by regulating the release of oxidised mitochondrial DNA via the frataxin (FXN)/ninjurin 1 (NINJ1) signalling pathway
Metformin exacerbates both acute and chronic pancreatitis, possibly because of increased release of Ox-mtDNA via modulation of mitochondrial iron homeostasis and NINJ1-mediated plasma membrane rupture, suggesting that extreme caution should be exercised when using metformin in diabetic patients with pancreatitis.
Authors
- Yilan Wang (ORCID: https://orcid.org/0000-0002-8230-4176)
- Xiuxian Yu
- Ao Wen
- Lijuan Feng (ORCID: https://orcid.org/0000-0002-2173-8210)
- Guang Xin (ORCID: https://orcid.org/0000-0002-1177-0671)
- Chengyu Wan
- Wen Huang (ORCID: https://orcid.org/0000-0002-9772-9492)
- Ke Li (ORCID: https://orcid.org/0000-0002-3140-3983)
- Yuman Dong
- Kun Zhang (ORCID: https://orcid.org/0000-0003-1236-6299)
- Tao Wang (ORCID: https://orcid.org/0000-0001-9845-3988)
- Shiyi Li (ORCID: https://orcid.org/0000-0002-1650-3249)
- Fan Li (ORCID: https://orcid.org/0000-0002-5944-3944)
- Qilong Zhou (ORCID: https://orcid.org/0000-0001-9640-4445)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1111/bph.70065
- Citations
- 4
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.03