Piperacillin-Tazobactam-Induced Generalized Exanthematous Pustulosis

Acute generalized exanthematous pustulosis (AGEP) is an extremely rare condition that is mostly caused by antibiotic exposure. Clinically, it manifests as the rapid appearance of multiple sterile pustules, swelling, and erythema within a few hours to days of exposure to the offending medication. Skin lesions usually resolve by desquamation after discontinuation of the offending agent. We present a case of a 58-year-old female patient with AGEP in the setting of piperacillin-tazobactam use, which was confirmed by histopathology with findings of neutrophilic pustules and eosinophilic infiltration. Her symptoms started resolving within three days of stopping the medication.