Biological potential, metabolite profiling and <scp><i>in silico</i></scp> analysis of pomelo (<scp><i>Citrus maxima</i></scp> L.) leaf
This study emphasizes the significance of selecting the most effective extraction methods to maximize the amount and biological activity of pomelo leaf extracts. Compounds number 16 (menadiol dibutyrate), 25 (5-[(4-hydroxypheny) ethenyl]-2-(3-methyl-1-butenyl)-1,3- benzenediol) and 51 (3-hydroxycoumarin) exhibited remarkable in silico activity as bioactive molecules against selected protein receptors, and are recommended for the further drug discovery and development. The findings offer valuable insights for the development of functional foods, nutraceuticals and pharmaceuticals derived from C. maxima L. leaves, highlighting their role in mitigating oxidative stress and preventing chronic diseases. The biological activity can pave the way for innovative applications in health and nutrition sectors. © 2025 Society of Chemical Industry.
Authors
- Dipak Kumar Sahoo (ORCID: https://orcid.org/0000-0003-3748-3395)
- Mehul Vaghamshi
- Mital Kaneria (ORCID: https://orcid.org/0000-0003-4498-6003)
- Ankit Faldu
- Anil Patani (ORCID: https://orcid.org/0000-0003-4401-8483)
- A.B. SAVALIYA
- Rabbani Syed (ORCID: https://orcid.org/0000-0003-4695-0645)
- Kalpna Rakholiya (ORCID: https://orcid.org/0000-0002-5911-2707)
- Mudassar Shahid (ORCID: https://orcid.org/0000-0003-3714-4772)
- Lokesh Yadav (ORCID: https://orcid.org/0000-0002-6652-0039)
- Ashish Patel (ORCID: https://orcid.org/0000-0003-4612-1724)
- Margi Patel
Institutions
- Iowa State University (US)
- Saurashtra University (IN)
- King Saud University (SA)
- Charotar University of Science and Technology (IN)
- Hemchandracharya North Gujarat University (IN)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1002/jsfa.14348
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00